Antibiotic resistance in Campylobacter

作者：Zhu, Jianguo; Zhang, Yanling; Hua, Xiuguo^*; Hou, Jianjun; Jiang, Yi

来源：Reviews in Medical Microbiology, 2006, 17(4): 107-112.

DOI：10.1097/mrm.0b013e3280c4d106

• antibiotic resistance
• Campylobacter
• epidemiology
• genetic basis

Antibiotic resistance has now emerged globally among thermophilic Campylobacter, including Campylobacter jejuni and Campylobacter coli, giving rise to speculation about what has triggered the development of this resistance. This review will focus on the association between antimicrobial use in food animals and the development of resistance in human isolates. The use of antimicrobial agents in food animals has caused concern regarding its impact on human health; there exists a close association between the amounts of antibiotics used and the levels of resistance, and the situation seems to be deteriorating more rapidly. By studying gene diversity of resistance patterns, some of the genetic determinants of antimicrobial resistance may prove useful as epidemiological markers. Resistance has been proved to be caused by the mutations in genes encoding the drugs' target enzymes, in genes encoding a multidrug efflux pump, as well as in 23S recombinant DNA of Campylobacter. In addition, horizontal genetic exchange is an important cause of antibiotic resistance in Campylobacter strains.

• 出版日期2006-12
• 单位上海交通大学