An efficient, general synthesis of racemic 2-substituted ferrocenecarboxaldehydes

作者：Garcia Jason; Moyano Albert^*; Rosol Malgorzata

来源：Tetrahedron, 2007, 63(9): 1907-1912.

DOI：10.1016/j.tet.2007.01.003

• aldehydes
• ferrocenes
• ortho-lithiation
• oxazolines

A straightforward, high-yielding route to racemic 2-substituted ferrocenecarboxaldehydes has been developed. The synthesis involves the ortho-lithiation/electrophilic quenching of readily accessible 2-ferrocenyl-4,4-dimethyloxazoline (2c), followed by N-methylation, sodium borohydride-mediated reduction, and acidic hydrolysis.

• 出版日期2007-2-26