The effect of two iso-caloric meals containing equal amounts of fats with a different fat composition on the inflammatory and metabolic markers in apparently healthy volunteers

作者：Raz Olga^*; Steinvil Arie; Berliner Shlomo; Rosenzweig Tovit; Justo Dan; Shapira Itzhak

来源：Journal of Inflammation, 2013, 10(1): 3.

DOI：10.1186/1476-9255-10-3

• Inflammation
• Monounsaturated fats
• Saturated fat
• Nutrition

Background: Little is known about the time-course of the postprandial appearance of macronutrient-induced inflammatory response. Our aim was to investigate the postprandial inflammatory and metabolic response following high fat, high caloric popular meals in apparently healthy participants.
Methods: Fifty four apparently healthy normal weight volunteers (BMI of 25.9 +/- 0.9) were given two iso-caloric meals with similar amounts but different composition of fats: a meal high in monounsaturated fats (MUFA), and a meal high in saturated fat (SFA). Three main effects and the interactions between them were analyzed: the time (before and 2 and 4 hours following the meals), the meal (MUFA or SFA) and the gender.
Results: The effect of time from the meal on hs-CRP level was highly significant (p=0.004). The highest responses were observed 2 hours after the meal (p=0.002). A statistically significant interaction was found between the time and the meal (p <= 0.0001), which reflects the higher increase in hs-CRP values 2 hours after the SFA meal, with no effect by the MUFA meal. The white blood cell counts were affected significantly by the time (p <= 0.0001) however, other inflammatory markers (fibrinogen, IL-6, TNF alpha, ICAM and VICAM) were not. All the metabolic markers (insulin, glucose, HOMA-R, QUICKI and triglycerides) were affected by the time (p <= 0.0001), with no interactions observed.
Conclusions: Metabolic and modest inflammatory changes occur within a few hours after the ingestion of a high SFA meal in apparently healthy adults.

• 出版日期2013-1-31