Xenocyloin Derivatives from Liquid Cultures of Xenorhabdus bovienii SN52

作者：Yu, Feng; Tian, Xiaomei; Sun, Ying; Bi, Yuhui; Yu, Zhiguo^*; Qin, Li^*

来源：Natural Product Communications, 2017, 12(12): 1851-1854.

DOI：10.1177/1934578x1701201209

• Xenorhabdus bovienii SN52
• Xenocyloin derivatives
• Anti-platelet aggregation activity

Members of genus Xenorhabdus are symbiotically associated with entomopathogenic nematodes of genus Steinernema. Herein, we describe the isolation and purification of four novel metabolites, xenocyloins G-J (1-4), from liquid cultures of Xenorhabdus bovienii SN52 by extensive column chromatography and semi-preparative HPLC. Chemical structures of the xenocyloin derivatives were determined based on comprehensive NMR spectra and HR-ESI-MS analyses. All compounds exhibited significant collagen-induced anti-platelet aggregation activities, among which xenocyloin H (2) exhibited the strongest activity with an inhibition rate of 96.0 +/- 0.1% at a concentration of 50 mu M. The xenocyloin G (1) and H (2) exhibited anti-platelet activities with IC50 values which were 31.7 +/- 4.4 mu M and 27.5 +/- 3.5 mu M respectively; whilst under similar conditions the IC50 value for aspirin was 289.5 +/- 15.7 mu M, nearly ten times less than 1 and 2.

• 出版日期2017-12
• 单位沈阳农业大学