Antibody Internalization into Living Cells via Cross linker-mediated Endocytosis

作者:Funamoto Daiki; Asai Daisuke; Sato Kazuki; Yamaguchi Yoko; Kim Chan Woo; Sato Hikari; Nakhaei Elnaz; Matsumoto Shingo; Yoshikawa Takuma; Sasaki Koichi; Yamamoto Tatsuhiro; Kishimura Akihiro; Mori Takeshi*; Katayama Yoshiki
来源:Chemistry Letters, 2015, 44(4): 468-470.
DOI:10.1246/cl.141157

摘要

We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This crosslinker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.

  • 出版日期2015-4-5

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