A comparative study of pentoxifylline effects in adult and aged rats submitted to lung dysfunction by thermal injury

作者：Ramallo Bianca Trovello; Loureco Elizete; Cruz Renata Harumi; Almeida Jacqueline Camargo; Taha Murched Omar; Okochi Alves Silva Priscilla Yuri; Oliveira Junior Itamar Souza

来源：Acta Cirurgica Brasileira, 2013, 28(2): 154-159.

DOI：10.1590/s0102-86502013000200012

• Burns
• Aging
• Lung Injury
• Cytokines
• Pentoxifylline
• Rats

PURPOSE: To investigate the protective effects of pentoxifylline against lung injury observed after dorsal scald in aged animals.
METHODS: Adult (eight months old) and aged (20 months old) rats were subjected to thermal injury or sham procedure. The six hours post-trauma animals received pentoxifylline and after 24 hours were euthanatized and lung tissue samples collectedted. The bronchoalveolar lavage fluid was evaluated for total protein content and tumor necrosis factor-alpha cytokine. Malondialdehyde and myeloperoxidase activety in the lung homogenate were measured and a histological lung examination was undertaken.
RESULTS: Burn injury induced oxidative stress in lung homogenate was higher in elderly-burned rats compared to adult-burned rats (p<0.001). Total protein and cytokine in bronchoalveolar lavage increased in the elderly-burned group when compared to the adult-burned group (p<0.001). All parameters decreased in bolth groups treated with pentoxifylline (p<0.05).
CONCLUSIONS: The injury was augmented in elderly rats when compared to adult rats. Damage was reduced with the use of pentoxifylline, however further studies are needed to evaluate the dose-response of the drug.

• 出版日期2013-2