Water mediated deprotective intramolecular hydroamination of N-propargylaminopyridines: synthesis of imidazo[1,2-alpha]pyridines

作者：Mohan Darapaneni Chandra; Sarang Niraj B; Adimurthy Subbarayappa^*

来源：Tetrahedron Letters, 2013, 54(45): 6077-6080.

DOI：10.1016/j.tetlet.2013.08.112

• N-propargylaminopyridines Imidazo[1,2-alpha]pyridine
• Hydroamination
• Synthesis
• Water

Metal-free synthesis of substituted imidazole [1,2-alpha]dpyridines from deprotective N-(prop-2-yn-1-yl)pyridin-2-amines in water is elucidated. Electron releasing substituents on pyridine ring provided pure products in quantitative yields without separation by column chromatography.

• 出版日期2013-11-6
• 单位海洋化工研究院有限公司