An efficient and facile synthesis of benzimidazo [1,2-a]benzimidazoles via copper-catalyzed domino addition/double cyclization

作者:Yuan Guodong; Liu Haiquan; Gao Jilong; Xu Hongjuan; Jiang Liu; Wang Xiaoxia; Lv Xin*
来源:RSC Advances, 2014, 4(42): 21904-21908.
DOI:10.1039/c4ra01181c

摘要

A copper-catalyzed synthesis of benzimidazo[1,2-a]benzimidazoles by domino addition/double cyclization of bis-(o-haloaryl)carbodiimides with primary amines was developed. A variety of the desired polycyclic benzimidazoles were efficiently and facilely assembled. Multibonds and polycyclic moieties were directly constructed in one pot. 2-Bromo-2'-iodo-diarylcarbodiimides gave good selectivity.