Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis

作者：Benesova Yvonne^*; Vasku Anna; Stourac Pavel; Hladikova Magdalena; Fiala Adam; Bednarik Josef

来源：Journal of Neuroimmunology, 2013, 255(1-2): 92-96.

DOI：10.1016/j.jneuroim.2012.10.014

• Gene
• HLA-DRB1*1501
• Multiple sclerosis
• Tagging polymorphism

We investigated the HIA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg=3.06 x 10(-8)) and allele frequency (Pa=6.08 x 10(-10)) between MS patients and controls was demonstrated. The homozygotes M and heterozygotes GA were more frequent in MS patients (OR=4.27, 95% CI: 2.64-6.92). %26lt;br%26gt;A significant difference between female MS patients and female controls in genotype distribution (Pg=1.3 x 10(-8)) and allele frequency (Pa=2.82 x 10(-8)); (OR=5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distribution of the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.

• 出版日期2013-2-15