Arsenic trioxide induces apoptosis in B-cell chronic lymphocytic leukemic cells through down-regulation of survivin via the p53-dependent signaling pathway

作者：Zhang, Xiao-Hui^*; Feng, Ru; Lv, Meng; Jiang, Qian; Zhu, Hong-Hu; Qing, Ya-Zhen; Bao, Jia-Ling; Huang, Xiao-Jun; Zheng, X. Long

来源：Leukemia Research, 2013, 37(12): 1719-1725.

DOI：10.1016/j.leukres.2013.09.019

• Arsenic trioxide
• WSU-CLL
• Apoptosis
• Survivin
• P53 and CLL

Arsenic trioxide (As2O3) can induce apoptosis in many tumors. However, the associated mechanisms are not clearly understood. We found that As2O3 significantly inhibited the proliferation of WSU-CLL cells and induced apoptosis in dose- and time-dependent manners. WSU-CLL cells treated with 2 mu M As2O3 showed survivin down-regulation and p53 up-regulation. Survivin siRNA combined with As2O3 further inhibited the proliferation of WSU-CLL cells. p53 inhibition by siRNA prevented the down-regulation of survivin by As2O3 and prevented the As2O3-induced cytotoxicity of WSU-CLL cells. These results suggest that As2O3 may be of therapeutic value for chronic lymphocytic leukemia.

• 出版日期2013-12
• 单位北京大学; 北京医院