Aqabamycins A-G: novel nitro maleimides from a marine Vibrio species: I. Taxonomy, fermentation, isolation and biological activities

作者：Al Zereini Wael; Yao Clarisse Blanchine Fotso Fondja; Laatsch Hartmut; Anke Heidrun^*

来源：Journal of Antibiotics, 2010, 63(6): 297-301.

DOI：10.1038/ja.2010.34

• antibacterial activity
• aqabamycins
• aromatic nitro compounds
• cytotoxic activity
• marine bacteria
• Vibrio species

In a screening of marine bacteria, a Vibrio species isolated from the surface of the soft coral Sinularia polydactyla collected in the Red Sea was found to be a prolific producer of secondary metabolites with antibacterial and cytotoxic activities. Seven novel maleimide derivatives named aqabamycin A (la), aqabamycin B (1b), aqabamycin C (1c), aqabamycin D (1d), aqabamycin E (1e and 1e'), aqabamycin F (1f) and aqabamycin G (2) were isolated together with several known metabolites such as 3-nitro-1H-indazole (3), indazole-3-carbaldehyde (4), phenyl-2-bis-indolylmethane (5a), turbomycin B (5b), vibrindole A (6), 1,4-dithiane (7), 3-(3-nitro-4-hydroxyphenyl)-2-propenoic acid (8), 3-nitro-4-hydroxybenzaldehyde (9), phenylacetic acid, benzoic acid, 3-hydroxybenzoic acid and 4-hydroxycinnamic acid. The aqabamycins, except aqabamycin A, bear a nitro group. Compounds 3, 4, 7 are described here for the first time from a natural source and vibrindole A was found to have cytotoxic activity. The Journal of Antibiotics (2010) 63, 297-301; doi:10.1038/ja.2010.34; published online 30 April 2010

• 出版日期2010-6