Ainsliadimer A, A new sesquiterpene lactone dimer with an unusual carbon skeleton from Ainsliaea macrocephala

作者：Wu, Zhi-Jun; Xu, Xi-Ke; Shen, Yun-Heng^*; Su, Juan; Tian, Jun-Mian; Liang, Shuang; Li, Hui-Liang; Liu, Rui-Hui; Zhang, Wei-Dong

来源：Organic Letters, 2008, 10(12): 2397-2400.

DOI：10.1021/ol800656q

• DIELS-ALDER REACTION
• ACERIFOLIA SCH BIP
• NITRIC-OXIDE
• SYNTHASE
• GUAIANOLIDES
• EXPRESSION
• FAMILY

A phytochemical investigation of Ainsliaea macrocephala led to the isolation of a new dimeric sesquiterpene lactone, ainsliadimer A (1). The structure of 1 was elucidated by spectroscopic analysis, and confirmed by single crystal X-ray diffraction. Ainsliadimer A represents an unusual carbon skeleton with a cyclopentane system connecting the two monomeric sesquiterpene lactone units. This unique molecule exerted potent inhibitory activity against the production of nitric oxide in RAW264.7 stimulated by LPS.

• 出版日期2008-6-19
• 单位上海交通大学; 中国人民解放军第二军医大学