科研之友
微信
新浪微博
Facebook
分享链接
摘要
AIM: To assess diffusion changes of the thalamus in Wilson's disease using diffusion tensor imaging (DTI). MATERIALS AND METHODS: Fifteen patients with Wilson's disease and an abnormal signal in the thalamus (designated as group 1) and 18 patients with Wilson's disease with a normal-appearing thalamus (designated as group 2) at conventional magnetic resonance imaging (MRI) were recruited. Fifteen age-matched and sex-matched healthy volunteers were also enrolled as the control group (designated as group 3). The fractional anisotropy (FA), primary eigenvalue (lambda 1), second eigenvalue (lambda 2), and third eigenvalue (lambda 3) of the thalamus were measured and the differences were compared. RESULTS: The FA values of the thalamus were different in the three groups (group 1: 0.36 /- 0.02; group 2: 0.38 /- 0.02; group 3: 0.43 /- 0.02; F = 54.51, p < 0.001). A statistically significant difference was observed between group 1 and group 2 (p = 0.003), group 1 and group 3 (p = 0.001), and group 2 and group 3 (p < 0.001). The lambda 1, lambda 2, and lambda 3 values of the thalamus were different in the three groups (1.11 /- 0.06 mm(2)/s, 1.11 /- 0.06 mm(2)/s, and 1.10 /- 0.04 mm(2)/s of lambda 1 in group 1, group 2, and group 3, respectively; 0.82 /- 0.08 mm(2)/s, 0.78 /- 0.05 mm(2)/s, and 0.72 /- 0.02 mm(2)/s of lambda 2 in group 1, group 2, and group 3, respectively; 0.52 /- 0.05 mm(2)/s, 0.49 /- 0.06 mm(2)/s, and 0.42 /- 0.06 mm(2)/s of lambda 3 in group 1, group 2, and group 3, respectively; F = 1.65, p = 0.203 of lambda 1; F = 10.55, p < 0.001 of lambda 2; F = 4.21, p = 0.021 of lambda 3; respectively). A statistically significant difference in the lambda 2 value was observed between group 1 and group 3 (p < 0.001) and group 2 and group 3 (p = 0.005). A statistically significant difference in the lambda 3 value was also observed between group 1 and group 3 (p = 0.007). No significant difference in the lambda 1 value was noted between each of the two groups. CONCLUSIONS: Damage of the thalamus in Wilson's disease patients can be detected using DTI. DTI may provide information regarding thalamus damage in patients with Wilson's disease before abnormal signals on conventional MRI.
- 出版日期2014-3
- 单位中山大学
