Novel Biodegradable Heterografted Polymer Brushes Prepared via a Chemoenzymatic Approach

作者：Hans Marc; Xiao Yan; Keul Helmut; Heise Andreas^*; Moeller Martin

来源：Macromolecular Chemistry and Physics, 2009, 210(9): 736-746.

DOI：10.1002/macp.200800590

• biodegradable
• chemoenzymatic
• enzymatic ring-opening polymerization
• grafting from
• molecular bottle brush

Biodegradable heterografted molecular bottle brushes were prepared in two steps starting with a linear polyglycidol as a macroinitiator. First, ca. 45% of the polyglycidol hydroxy groups were grafted with epsilon-caprolactone via enzymatic catalysis. Selective end capping of the hydroxy groups at the graft ends was achieved via enzymatic esterification with vinyl acetate or vinyl acrylate. Finally, poly(L-lactide) grafts were attached to the remaining polyglycidol hydroxy groups by chemically catalyzed ring-opening polymerization. The successful synthesis of the heterografted comb-shaped brushes was confirmed by NMR and SEC analyses. Additionally, the feasibility of microsphere formulation was described.

• 出版日期2009-5-6