Untangling the Web of Systemic Autoinflammatory Diseases

作者：Rigante Donato; Lopalco Giuseppe; Vitale Antonio; Lucherini Orso Maria; Caso Francesco; De Clemente Caterina; Molinaro Francesco; Messina Mario; Costa Luisa; Atteno Mariangela; Laghi Pasini Franco; Lapadula Giovanni; Galeazzi Mauro; Iannone Florenzo; Cantarini Luca^*

来源：Mediators of Inflammation, 2014, 2014: 948154.

DOI：10.1155/2014/948154

Theinnateimmune system is involved in the pathophysiology of systemic autoinflammatory diseases (SAIDs), an enlarging group of disorders caused by dysregulated production of proinflammatory cytokines, such as interleukin-1 beta and tumor necrosis factor-alpha, in which autoreactive T-lymphocytes and autoantibodies are indeed absent. A widely deranged innate immunity leads to overactivity of proinflammatory cytokines and subsequent multisite inflammatory symptoms depicting various conditions, such as hereditary periodic fevers, granulomatous disorders, and pyogenic diseases, collectively described in this review. Further research should enhance our understanding of the genetics behind SAIDs, unearth triggers of inflammatory attacks, and result in improvement for their diagnosis and treatment.

• 出版日期2014