Stentless xenografts as an alternative to pulmonary homografts in the Ross operation

作者：Hechadi Jawad; Gerber Bernhard L; Coche Emmanuel; Melchior Julie; Jashari Ramadan; Glineur David; Noirhomme Philippe; Rubay Jean; El Khoury Gebrine^*; De Kerchove Laurent

来源：European Journal of Cardio-Thoracic Surgery, 2013, 44(1): E32-E39.

DOI：10.1093/ejcts/ezt147

• Ross procedure
• Pulmonary valve
• Pulmonary homograft
• Stentless bioprosthesis

OBJECTIVES: Because of the limited availability of pulmonary homografts (PH), porcine stentless xenografts (SX) have been proposed as an alternative for pulmonary valve replacement in the Ross operation. However, it is unknown whether they have similar good long-term durability. Therefore, we compared mid-to long-term outcomes between those two right ventricular outflow tract (RVOT) substitutes. %26lt;br%26gt;METHODS: In 288 adults (%26gt;18 years) undergoing a Ross operation between 1991 and 2012, Freestyle (R) SX was used in 18 patients and a cryopreserved PH was used in 270 for RVOT reconstruction. Only patients with follow-up %26gt;2 years were included. According to the operative period, gender and age, 37 patients with PH could be matched with 17 SX patients. Clinical and echocardiographic follow-up were obtained. In a subset of patients (SX, n = 11 and PH, n = 25), a cardiac computed tomographic (CT) scan was performed to analyse graft calcification. %26lt;br%26gt;RESULTS: The mean follow-up period was 8.2 +/- 4.0 (range 2-14.6 years). During this period, 3 patients died from cancer, 2 in the SX group and 1 in the PH group (P = 0.15). No patient needed RVOT reoperation. At follow-up, RVOT peak gradient was 21 +/- 5.9 mmHg in the SX and 16.3 +/- 8.7 in the PH groups (P = 0.07). Peak gradient %26gt;40 mmHg was observed in only 1 patient in the PH group. Mean RVOT regurgitation was 0.1 +/- 0.4 in the SX group and 0.8 +/- 0.6 in the PH group (P = 0.008). CT scan analyses showed progressive calcification mainly of the graft wall, while the valve remained relatively free of calcium. Patients with the SX presented significantly higher calcium scores than those with PH (P = 0.01). %26lt;br%26gt;CONCLUSIONS: In adult patients having the Ross operation, calcic degeneration is observed in both the PH and the SX used as pulmonary substitutes. Calcification progresses more rapidly in the SX compared with the PH. In both grafts, calcifications affect mainly the wall, while the valve remains relatively free of calcium. As a consequence, both grafts show good and similar haemodynamic outcomes at mid-to long-term follow-up. The Freestyle (R) SX can be considered as an acceptable alternative for RVOT reconstruction when PH is not available.

• 出版日期2013-7