Aerogel Microspheres from Natural Cellulose Nanofibrils and Their Application as Cell Culture Scaffold

作者：Cai, Hongli; Sharma, Sudhir; Liu, Wenying; Mu, Wei; Liu, Wei; Zhang, Xiaodan; Deng, Yulin^*

来源：Biomacromolecules, 2014, 15(7): 2540-2547.

DOI：10.1021/bm5003976

• SURFACE-AREA
• DELIVERY
• CARRIERS
• AEROCELLULOSE
• ABSORPTION
• HYDROXIDE
• NANOPAPER
• POLYMERS
• BULK

We demonstrated that ultralight pure natural aerogel microspheres can be fabricated using cellulose nanofibrials (CNF) directly. Experimentally, the CNF aqueous gel droplets, produced by spraying and atomizing through a steel nozzle, were collected into liquid nitrogen for instant freezing followed by freeze-drying. The aerogel microspheres are highly porous with bulk density as low as 0.0018 g cm(-3). The pore size of the cellulose aeogel microspheres ranges from nano- to macrometers. The unique ultralight and high porous structure ensured high moisture (similar to 90 g g(-1)) and water uptake capacity (similar to 400 g g(-1)) of the aerogel microspheres. Covalent cross-linking between the native nanofibrils and cross-linkers made the aerogel microspheres very stable even in a harsh environment. The present study also confirmed this kind of aerogel microspheres from native cellulose fibers can be used as cell culture scaffold.

• 出版日期2014-7
• 单位吉林大学