A novel delayed non-match to sample object recognition task that allows simultaneous in vivo microdialysis

作者：Ihalainen Jouni^*; Sarajarvi Timo; Kemppainen Susanna; Keski Rahkonen Pekka; Lehtonen Marko; Tanila Heikki

来源：Journal of Neuroscience Methods, 2010, 189(2): 210-215.

DOI：10.1016/j.jneumeth.2010.04.006

• Acetylcholine
• Behavior
• Delayed non-match to sample
• In vivo microdialysis
• Learning and memory
• Object recognition task
• Rat

We present a modification of the widely used delayed non-match to sample (DNMS) paradigm for assessment of object recognition memory that can be combined with simultaneous in vivo microdialysis. The present study provides evidence that hippocampal ACh release increases from baseline during active exploration of the test environment and an empty test board, but a specific further increase is seen during the recognition memory task performance. This novel experimental model offers a good tool to study the impact of selective lesions or pharmacological manipulation simultaneously on neurotransmitter levels and memory task performance.

• 出版日期2010-6-15