Dose-Response Analysis Using R

作者：Ritz, Christian^*; Baty, Florent; Streibig, Jens C.; Gerhard, Daniel

来源：PLos One, 2015, 10(12): e0146021.

DOI：10.1371/journal.pone.0146021

• NONLINEAR-REGRESSION
• SIMULTANEOUS INFERENCE
• MODEL
• TRANSFORMATIONS
• BIOASSAY
• POTENCY
• PACKAGE
• GROWTH

Dose-response analysis can be carried out using multi-purpose commercial statistical software, but except for a few special cases the analysis easily becomes cumbersome as relevant, non-standard output requires manual programming. The extension package drc for the statistical environment R provides a flexible and versatile infrastructure for dose-response analyses in general. The present version of the package, reflecting extensions and modifications over the last decade, provides a user-friendly interface to specify the model assumptions about the dose-response relationship and comes with a number of extractors for summarizing fitted models and carrying out inference on derived parameters. The aim of the present paper is to provide an overview of state-of-the-art dose-response analysis, both in terms of general concepts that have evolved and matured over the years and by means of concrete examples.

• 出版日期2015-12-30