Medial prefrontal dysfunction and prolonged amygdala response during instructed fear processing in borderline personality disorder

作者：Kamphausen Susanne; Schroeder Patricia; Maier Simon; Bader Kerstin; Feige Bernd; Kaller Christoph P; Glauche Volkmar; Ohlendorf Sabine; van Elst Ludger Tebartz; Kloeppel Stefan; Jacob Gitta A; Silbersweig David; Lieb Klaus; Tuescher Oliver

来源：World Journal of Biological Psychiatry, 2013, 14(4): 307-318.

DOI：10.3109/15622975.2012.665174

• Borderline personality disorder (BPD)
• fMRI
• instructed fear
• amygdala
• vmPFC

Objectives. Affective dysregulation is a clinical hallmark of borderline personality disorder (BPD). This study used an instructed fear task combined with functional MRI (fMRI) and skin conductance response (SCR) to test hypotheses about mechanisms of disturbed fronto-limbic neural circuitry underlying dysfunctional emotional processing in BPD. Methods. Female BPD patients and matched control subjects were exposed to two visual stimuli during fMRI scanning and SCR recording. Subjects were instructed shortly before scanning that one stimulus (Threat) potentially represents an aversive event whereas another stimulus (Safe) represents safety. The aversive event (electrodermal stimulation) itself was only experienced before this instruction and never occurred during fMRI scanning. Results. Both groups showed stronger SCR to Threat compared to Safe indicating differential fear response which habituated over time. BPD compared to control subjects did not show fMRI signal decrease of amygdala activity or relative ventromedial prefrontal cortex (vmPFC) activity increase over time. Moreover, BPD patients showed increased connectivity of the amygdala with vmPFC but decreased connectivity of subgenual ACC with dorsal ACC compared to control subjects. Conclusions. Prolonged amygdala response and a functional disconnection between ventral and dorsal mPFC regions may be part of the neural mechanisms underlying emotional dysregulation in BPD patients.

• 出版日期2013-5