Postoperative peak serum C-reactive protein is a predictor of outcome following liver transplantation for hepatocellular carcinoma

作者：Kornberg Arno^*; Witt Ulrike; Kornberg Jennifer; Mueller Katharina; Friess Helmut; Thrum Katharina

来源：Biomarkers, 2016, 21(2): 152-159.

DOI：10.3109/1354750X.2015.1118548

• ischemia-reperfusion injury
• tumor recurrence
• liver transplantation
• Inflammation
• Milan criteria

Context: C-reactive protein (CRP), a biomarker of inflammation, may correlate with prognosis in several malignancies.
Objective: To investigate the prognostic impact of early postoperative peak serum levels of CRP on tumor-specific outcome in 106 liver transplant patients with hepatocellular carcinoma (HCC).
Methods and results: In multivariate Cox regression analysis, a posttransplant elevated peak CRP level (>versus <= 3.5 mg/dl) was identified as an independent predictor of poor recurrence-free survival (p = 0.01; HR = 4.04; CI = 1.399-11.640).
Conclusion: Early postoperative serum CRP may serve as a useful inflammation-based biomarker of outcome in liver transplant patients with HCC.

• 出版日期2016-2-17