Asthma Pharmacotherapy

作者：Schofield Minka L^*

来源：Otolaryngologic Clinics of North America, 2014, 47(1): 55-+.

DOI：10.1016/j.otc.2013.09.011

• Asthma
• Therapy
• Medications
• Short acting beta agonists
• Inhaled corticosteroids
• Long acting beta agonists
• Anti-IgE therapy

Asthma is a chronic inflammatory disease of the airway that leads to airway obstruction via bronchoconstriction, edema, and mucus hypersecretion. The National Asthma Education and Prevention Program has outlined evidence-based guidelines to standardize asthma therapy and improve outcomes. The initial recommendation of choice for persistent asthmatic patients is an inhaled corticosteroid (ICS). Long-acting beta-2 agonists in combination with ICS, oral corticosteroids, leukotriene modifiers, and anti-IgE therapeutic options can be considered for patients with persistent or worsening symptoms. Many novel therapies are being developed, with an emphasis on anti-inflammatory mechanisms, gene expression, and cytokine modification.

• 出版日期2014-2