No cookie-cutter oncology: individualized treatment approaches for women with corpus endometrial cancer

作者：Feddock Jonathan^*; Kudrimoti Mahesh; Randall Marc

来源：Expert Review of Anticancer Therapy, 2010, 10(7): 1087-1100.

DOI：10.1586/ERA.10.85

• chemotherapy
• endometrial cancer
• lymph node dissection
• radiation therapy
• staging

Endometrial adenocarcinoma is the most common gynecologic malignancy and, for the majority of patients who present with stage I (similar to 70%) or stage II (similar to 10%) disease, 5-year overall survival rates approach 85%. However, the complicated mix of medical comorbidities, the broad spectrum of techniques and treatment modalities and controversial clinical trial outcomes makes treating this heterogeneous group of patients unique and challenging. Similar management controversies exist and, when one factors in histologic variability, no flow-chart treatment algorithm can be easily constructed. This article will discuss data from key clinical trials, consider the role of routine lymphadenectomy as a component of surgical staging, discuss the heterogeneity of stage III patients in both presentation and response to treatment, review options for medically inoperable patients and reflect on current and upcoming protocols.

• 出版日期2010-7