Direct conversion of epoxides into aziridines with N-arylphosphorarnidates

作者：Minicone Fabrizio; Rogers Wendy J; Green James F J; Khan Mommna; Smith Geoffrey M T; Bray Christopher D^*

来源：Tetrahedron Letters, 2014, 55(43): 5890-5891.

DOI：10.1016/j.tetlet.2014.08.009

• Aziridine
• Epoxide
• Phosphoramidate
• Ring-opening
• Anion-relay

Treatment of terminal epoxides with N-arylphosphoramidate anions leads directly to N-aryl aziridines. Existing methods for this transformation employ either multi-step syntheses or an iminophosphorane in conjunction with a Lewis acid. The described method therefore presents an advantage in terms of brevity and atom economy.

• 出版日期2014-10-22