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摘要
The aim of the present study was to improve our understanding of cadmium bioavailability by linking toxicokinetics and toxicodynamics. The springtail Folsomia candida was exposed to different cadmium concentrations in solutions embedded in inert quartz sand. Survival and cadmium uptake in the animals were followed for 21 d. After 10 d, some animals were transferred to clean medium to assess cadmium elimination. Using a first-order one-compartment model, an overall uptake rate constant (k(1)) of 0.18 L kg(animal)(-1) d(-1) and an elimination rate constant (k(2-TK)) of 0.02 d(-1) were calculated. Survival decreased with time, resulting in an estimated final median lethal concentration (LC50) of 0.51 mM. A lethal body concentration (LBC) of 4.6 mu mol Cd g(-1) dry body weight was estimated by multiplying the final LC50 by the bioconcentration factor (k(1)/k(2-TK)). The LC50(animal) values based on internal cadmium concentrations were between 3.56 mu mol Cd g(-1) and 9.91 mu mol Cd g(-1) dry body weight, with an overall value of 7.9 mu mol Cd g(-1) dry body weight (95% confidence interval [CI]: 3.8-12.0 mu mol Cd g(-1) dry body wt). Because the 95% CI of the LC50(animal) included the LBC, there was good agreement of cadmium toxicokinetics and toxicodynamics.
- 出版日期2014-7
