Association of gene polymorphisms of pattern-recognition receptor signaling pathway with the risk and severity of hand, foot, and mouth disease caused by enterovirus 71 in Chinese Han population

作者：Li Ya Ping; Li Mei; Jia Xiao Li; Deng Hui Ling; Wang Wen Jun; Wu Feng Ping; Wang Jun; Dang Shuang Suo

来源：Journal of Medical Virology, 2018, 90(4): 692-698.

DOI：10.1002/jmv.25000

• enterovirus 71
• gene polymorphism
• hand foot and mouth disease
• pattern recognition receptors
• risk factors

Hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) presents with a wide variety of clinical manifestations. Host immune response is a factor that influences disease susceptibility and severity. We investigated the potential association of gene polymorphisms in the pattern recognition receptor (PRR) pathway with the risk and severity of EV71 infection. A total of 180 EV71 HFMD cases (108 severe case; 72 mild cases) were enrolled. A group of 201 sex- and age-matched children was included as a control. All subjects were genotyped for the most common single-nucleotide polymorphisms (SNPs) in the PRR and the PRR signaling pathway using the SNPscan multiple SNP typing method. Binary logistic regression analysis revealed statistically significant differences in polymorphism of RIG-1 between patients and controls (rs3739674 G vs C: OR=1.502, 95%CI: 1.120-2.014; rs9695310 G vs C: OR=1.782, 95%CI: 1.312-2.419). Polymorphisms of RIG-1 rs3739674 (G vs C: OR=2.047, 95%CI: 1.307-3.205) and TLR3 rs5743305 (A vs T: OR=0.346, 95%CI: 0.212-0.566) were found to be associated with disease severity. The results indicated that RIG-1 (rs3739674 and rs9695310) polymorphisms are associated with an increased risk of EV71-induced HFMD in Chinese children, whereas RIG-1 rs3739674 and TLR3 rs5743305 polymorphisms are associated with disease severity. These findings support an important role of innate immune mechanism in EV71 infection.

• 出版日期2018-4
• 单位西安交通大学