Autophagy takes an alternative pathway

作者：Shimizu Shigeomi^*; Arakawa Satoko; Nishida Yuya

来源：Autophagy, 2010, 6(2): 290-291.

DOI：10.1038/nature08455

• alternative macroautophagy
• Rab9
• trans-golgi
• reticulocyte
• Atg5
• LC3

ATG5 and ATG7 are considered as essential molecules for induction of macroautophagy. However, we found that cells lacking ATG5 or ATG7 can still form autophagosomes/autolysosomes and perform autophagy-mediated protein degradation when subjected to certain stresses. Although lipidation of LC3 is accepted to be a good indicator of macroautophagy, it did not occur during the ATG5/ATG7-independent alternative macroautophagy. Unlike conventional macroautophagy, autophagosomes seemed to be generated in a Rab9-dependent manner by the fusion of the phagophore with vesicles derived from the trans-Golgi and late endosomes. Mammalian macroautophagy can occur via at least two different pathways, which are an ATG5/ATG7-dependent conventional pathway and an ATG5/ATG7-independent alternative pathway.

• 出版日期2010-2-16