Pestalactams A-C: novel caprolactams from the endophytic fungus Pestalotiopsis sp.

作者：Davis Rohan A^*; Carroll Anthony R; Andrews Katherine T; Boyle Glen M; Tran Truc Linh; Healy Peter C; Kalaitzis John A; Shivas Roger G

来源：Organic and Biomolecular Chemistry, 2010, 8(8): 1785-1790.

DOI：10.1039/b924169h

Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A(1) and B(2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays.

• 出版日期2010
• 单位河北医科大学