Nanocrystalline copper(II) oxide catalyzed aza-Michael reaction and insertion of alpha-diazo compounds into N-H bonds of amines

作者：Kantam M Lakshmi^*; Laha Soumi; Yadav Jagjit; Jha Shailendra

来源：Tetrahedron Letters, 2009, 50(31): 4467-4469.

DOI：10.1016/j.tetlet.2009.05.059

• Nanocrystalline copper(II) oxide
• Heterogeneous catalyst
• Aza-Michael addition
• alpha,beta-Unsaturated compounds
• Insertion
• Diazoacetate

Nanocrystalline copper(II) oxide efficiently catalyzed the conjugate addition of aliphatic amines to alpha,beta-unsaturated compounds to produce beta-amino compounds with excellent yields under mild reaction conditions. Similarly, Glycine esters are obtained in good yields by the insertion of alpha-diazoacetate into N-H bonds of amines. The catalyst is used for three cycles with minimal loss of activity.

• 出版日期2009-8-5