Arterial Stiffness, Lipoprotein Particle Size, and Lipoprotein Particle Concentration in Children with Type 1 Diabetes

作者：Gallo Lisa M^*; Silverstein Janet H; Shuster Jonathan J; Haller Michael J

来源：Journal of Pediatric Endocrinology & Metabolism, 2010, 23(7): 661-667.

• type 1
• adolescents
• children
• arterial stiffness
• lipoprotein particles

Objective: To determine if lipoprotein particle abnormalities correlate with arterial stiffness in children with type 1 diabetes (T1D).
Study Design: In this case-control study, we evaluated 70 children, 35 with T1D and 35 controls, ages 10-18 years, matched for age, sex, race, and BMI. Arterial stiffness was assessed by radial tonometry (AI(75)) and blood was collected for lipoprotein subclass analysis.
Results: T1D subjects had increased AI(75), decreased small LDL particle concentration (P=0.0067), increased large LDL particle concentration (P=0.007), increased large HDL particle concentration (P=0.0012), increased mean LDL particle size (P=0.0028), and increased mean HDL particle size (P<0.0001) compared to controls. No significant correlations were found between lipoprotein subclasses and arterial stiffness in T1D subjects.
Conclusions: T1D subjects have increased arterial stiffness when compared to controls, despite a less pro-atherogenic lipoprotein profile, indicating the need to identify other risk factors that correlate with arterial stiffness in T1D youth.

• 出版日期2010-7