Association between peroxisome proliferator-activated receptor γ gene polymorphism and susceptibility to northwest dryness syndrome

作者：Wang Yan; Wang Xiaozhong; Zeng Binfang^*; Guo Feng; He Yongquan; He Jiaying; Liu Bin

来源：Journal of Traditional Chinese Medicine, 2017, 37(2): 201-206.

DOI：10.1016/s0254-6272(17)30045-6

• PPAR gamma
• Polymorphism, genetic
• Genotype
• Northwest dryness syndrome

OBJECTIVE: To investigate the relationship between gene polymorphism of peroxisome proliferator-activated receptor (PPAR) and susceptibility to northwest dryness syndrome (NDS). @@@ METHODS: The polymorphisms of 11 PPAR gamma gene loci rs10510418, rs12633551, rs1373640, rs17036188, rs2921190, rs4135247, rs4135275, rs4135283, rs6768587, rs709156, and rs7615916 were detected in 249 patients with NDS and 260 patients with non-NDS (control group) by using Snapshot single-nucleotide polymorphism typing technology. @@@ RESULTS: All locus detections were in accordance with Hardy-Weinberg equilibrium test. Compared with the control group, rs2921190 genotype frequency showed statistical difference in the NDS group (P < 0.05). Two-two comparison result showed that CC genotype frequency in the NDS group was higher than that in the control group. CT and TT genotype distribution frequencies showed differences between the two groups. The rare allele frequency in the NDS group was lower than that of the control group (P < 0.01). Multi-factor logistic regression analysis showed that the age and genotype entered the regression equation. The subjects in the age bracket 30-55 and 45-45 were 1.796 and 1.561 times likely, respectively, than those in other age brackets to contract NDS,. The patients with CC genotype was only 0.524 times likely than those with CT/TT genotype to suffer from NDS. @@@ CONCLUSION: PPAR gamma gene rs2921190 polymorphism was correlated with the susceptibility to NDS.

• 出版日期2017-4
• 单位新疆维吾尔自治区第六人民医院; 新疆医科大学