Dihydroresveratrol cellobioside and xylobioside as effective melanogenesis activators

作者：Oode Chisato; Shimada Wataru; Yokota Mariko; Yamada Yoichi; Nihei Ken ichi

来源：Carbohydrate Research, 2016, 436: 45-49.

DOI：10.1016/j.carres.2016.11.004

• Dihydroresveratrol cellobioside
• Dihydroresveratrol xylobioside
• Glycosylation
• Melanogenesis inhibitor
• Melanogenesis activator

Dihydroresveratrol cellobioside and xylobioside, whose structures were designed based on that of the naturally occurring melanogenesis-controlling agent dihydroresveratrol glucoside, were synthesized via Schmidt glycosylation as the key step. Both analogues stimulated melanogenesis with efficacies comparable to that of 8-methoxypsoralen, a well-known melanogenesis activator. This suggests that diglycosyl modification of the 4'-OH on the dihydroresveratrol skeleton leads to the activation of melanogenesis, both with and without hydroxymethyl groups in the sugar moieties.

• 出版日期2016-12-21