A novel iridium/acid co-catalyzed transfer hydrogenative C(sp(3))-H bond alkylation to access functionalized N-heteroaromatics

作者：Tan, Zhenda; Jiang, Huanfeng; Zhang, Min^*

来源：Chemical communications, 2016, 52(60): 9359-9362.

DOI：10.1039/c6cc03996k

• ASYMMETRIC ALPHA-ALKYLATION
• DIRECT BETA-ALKYLATION
• OXIDATIVE ALKYLATION
• MOLECULAR-OXYGEN
• SIMPLE OLEFINS
• CYCLIC AMINES
• ALDEHYDES
• DEHYDROGENATION
• ARYLATION
• HETEROCYCLES

A novel iridium/acid co-catalysed transfer hydrogenative coupling strategy, enabling direct alkylation of C(sp(3))-H bonds and atomeconomic access to alkyl chain-lengthened N-heteroaromatics from six-membered 2-alkyl cyclic amines and aldehydes, has been demonstrated. This work has built an important basis to convert cyclic amines, a class of bulk chemical raw materials, into functionalized products.

• 出版日期2016
• 单位华南理工大学