A New Method for Selective Deprotection of Anomeric N,O-Dimethylhydroxylamine Promoted by TMSCl

作者:Huang Shengjun*; Liao Jun; Zhao Qingjie; Chai Xiaoyun; Wang Baogang; Yu Shichong; Wu Qiuye
来源:Journal of Carbohydrate Chemistry, 2013, 32(2): 158-168.
DOI:10.1080/07328303.2012.762104

摘要

TMSCl was shown to be an efficient reagent for selective deprotection of the anomeric position protected as N, O-dimethylhydroxylamine glycoside. This deprotection condition was proved to be compatible with a number of protecting groups, such as the TB-DPS, acetyl, benzyl, benzylidene, and benzoyl groups.