In Vitro Virucidal Effect of Mouthrinse Containing C31G on Seasonal Influenza Viruses

作者：Lee Dong Hun; Youn Ha Na; Park Jae Keun; Kang Byung Hwa; Kang Jae Hoon; Lee Joong Bok; Park Seung Yong; Choi In Soo; Lee Sang Won; Song Chang Seon^*

来源：Journal of Microbiology and Biotechnology, 2014, 24(7): 921-924.

DOI：10.4014/jmb.1312.12055

• Mouthrinse
• C31G
• gargle
• influenza virus

C31G is a potent antimicrobial agent and can disrupt the microbial membrane by the alkyl portion of the molecule. The objective of this study was to evaluate the virucidal effectiveness of C31G and mouthrinse containing C31G (Sense-Time) on seasonal influenza viruses. Evaluation of the virucidal activity against influenza viruses was performed with end-point titration in 10-day-old chicken embryos and Madin-Darby canine kidney cells. In vitro studies demonstrated that C31G and Sense-Time inhibited the growth of seasonal influenza viruses even in the presence of 5% organic material. Gargling with C31G or Sense-Time would enhance oropharyngeal hygiene, which would be helpful for reducing influenza transmission.

• 出版日期2014-7