A quantitative kinetic model for ATP-induced intracellular Ca2+ oscillations

作者：Wang Jinhui; Huang Xudong; Huang Weidong^*

来源：Journal of Theoretical Biology, 2007, 245(3): 510-519.

DOI：10.1016/j.jtbi.2006.11.007

• calcium oscillations
• sudden disappearance
• biphasic release
• endoplasmic reticulum
• quantitative model

A quantitative kinetic model is proposed to simulate the ATP-induced intracellular Ca2+ oscillations. The quantitative effect of ATP concentration upon the oscillations was successfully simulated. Our simulation results support previous experimental explanations that the Ca2+ oscillations are mainly due to interaction of Ca2+ release from the endoplasmic reticulum (ER) and the ATP-dependent Ca2+ pump back into the ER, and the oscillations are prolonged by extracellular Ca2+ entry that maintains the constant Ca2+ supplies to its intracellular stores. The model is also able to simulate the sudden disappearance phenomenon of the Ca2+ oscillations observed in some cell types by taking into account of the biphasic characteristic of the Ca2+ release from the endoplasmic reticulum (ER). Moreover, the model simulation results for the Ca2+ oscillations characteristics such as duration, peak [Ca2+](cyt), and average interval, etc., lead to prediction of some possible factors responsible for the variations of Ca2+ oscillations in different types of cells.

• 出版日期2007-4-7
• 单位中国科学技术大学