A Circadian Output Circuit Controls Sleep-Wake Arousal in Drosophila

作者：Guo, Fang^*; Holla, Meghana; Diaz, Madelen M.; Ro**ash, Michael^*

来源：Neuron, 2018, 100(3): 624-+.

DOI：10.1016/j.neuron.2018.09.002

• MUSHROOM BODIES
• CENTRAL COMPLEX
• CLOCK NEURONS
• VISUAL INPUT
• MELANOGASTER
• BEHAVIOR
• MODEL
• ORGANIZATION
• POPULATIONS
• RHYTHMS

The Drosophila core circadian circuit contains distinct groups of interacting neurons that give rise to diurnal sleep-wake patterns. Previous work showed that a subset of dorsal neurons 1 (DN1s) are sleep-promoting through their inhibition of activity-promoting circadian pacemakers. Here we show that these anterior-projecting DNs (APDNs) also "exit" the circadian circuitry and communicate with the homeostatic sleep center in higher brain regions to regulate sleep and sleep-wake arousal. These APDNs connect to a small, discrete subset of tubercular-bulbar neurons, which are connected in turn to specific sleep-centric ellipsoid body (EB)-ring neurons of the central complex. Remarkably, activation of the APDNs produces sleep-like oscillations in the EB and affects arousal. The data indicate that this APDN-Tu Bu-sup-EB circuit temporally regulates sleep-wake arousal in addition to the previously defined role of the TuBu-EB circuit in vision, navigation, and attention.

• 出版日期2018-11-7
• 单位浙江大学