Detection and compensation of organ/lesion motion using 4D-PET/CT respiratory gated acquisition techniques

作者：Bettinardi Valentino^*; Picchio Maria; Di Muzio Nadia; Gianolli Luigi; Gilardi Maria Carla; Messa Cristina

来源：Radiotherapy and Oncology, 2010, 96(3): 311-316.

DOI：10.1016/j.radonc.2010.07.014

• Respiratory organ motion
• Respiratory gated 4D-PET/CT
• Radiotherapy

Purpose: To describe the degradation effects produced by respiratory organ and lesion motion on PET/CT images and to define the role of respiratory gated (RG) 4D-PET/CT techniques to compensate for such effects. Methods: Based on the literature and on our own experience, technical recommendations and clinical indications for the use of RG 4D PET/CT have been outlined.
Results: RC 4D-PET/CT techniques require a state of the art PET/CT-scanner, a respiratory monitoring system and dedicated acquisition and processing protocols. Patient training is particularly important to obtain a regular breathing pattern. An adequate number of phases has to be selected to balance motion compensation and statistical noise. RG 4D PET/CT motion free images may be clinically useful for tumour tissue characterization, monitoring patient treatment and target definition in radiation therapy planning. Conclusions: RG 4D PET/CT is a valuable tool to improve image quality and quantitative accuracy and to assess and measure organ and lesion motion for radiotherapy planning. 2010 European Society for Therapeutic Radiology and Oncology and European Association of Nuclear Medicine. Published by Elsevier Ireland Ltd.

• 出版日期2010-9