Urinary and serum titanium - Assessment as an indicator of exposure to ammonium citratoperoxotitanate(IV) and its influence on renal function

作者：Nakasuji K^*; Usuda K; Kawasaki T; Dote E; Hayashi S; Mitsui G; Adachi K; Fujihara M; Shimbo Y; Kono K

来源：Biological Trace Element Research, 2006, 110(2): 119-131.

DOI：10.1385/BTER:110:2:119

• ICP-AES
• ammonium citratoperoxotitanate (IV)
• photocatalyst
• urinary titanium
• serum titanium
• renal toxicity

Ammonium citratoperoxotitanate IV (TAS-FINE) is a water-soluble titanium complex used to synthesize a photocatalytic titanium(IV) oxide film. This study was aimed to investigate the LD50, dose-response, time-course response, and renal toxicity of TAS-FINE using an animal model. Serum titanium (S-Ti) and its 24-h urinary excretion (U-Ti) were determined by inductively coupled plasma-argon emission spectrometry (ICPAES) after a single oral TAS-FINE administration to male Wistar rats. The LD50 of TAS-FINE was 7.97 g/kg body weight in 24 h, and its half-life was 3.78 +/- 1.28 d for S-Ti and 2.19 +/- 0.09 d for U-Ti. Although TAS-FINE was not easily absorbed in the gastrointestinal tract, it was distributed into the bloodstream in a dose-dependent manner. Within 24 h, 0.189% of administrated Ti was excreted via urine. It was speculated that TAS-FINE formed conjugates with serum constituents that resulted in nephrotoxicity resulting from an allergic reaction. The observed indices in this study were revealed to be good indicators for TAS-FINE exposure. The analytical method and animal model described in this study will help to further elucidate details about human exposure to TAS-FINE, which in recent times has become an occupational and environmental toxicant of concern.

• 出版日期2006-5