A RARE COMPLEMENT COMPONENT C4 RESTRICTION-FRAGMENT-LENGTH-POLYMORPHISM IN 2 FAMILIES WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

作者：GOLDSTEIN R^*; MOULDS JM; SENGAR DPS

来源：Journal of Rheumatology, 1991, 18(3): 345-348.

• COMPLEMENT COMPONENT-C4
• RFLP
• SYSTEMIC LUPUS ERYTHEMATOSUS

C4 null alleles with or without C4A,21-OHA gene deletions are associated with systemic lupus erythematosus (SLE) in various populations. We describe a new, rare C4 restriction fragment length polymorphism (RFLP), a Taq I 3.5 kb fragment, in 2 patients with SLE and their families. This RFLP is not associated with one particular major histocompatibility complex (MHC) haplotype and has not been reported in patients with SLE, patients with congenital adrenal insufficiency, or in healthy individuals.

• 出版日期1991-3