Steroidogenic factor-1 and endometriosis

作者：Bulun Serdar E^*; Utsunomiya Hiroki; Lin Zhihong; Yin Ping; Cheng You Hong; Pavone Mary E; Tokunaga Hideki; Trukhacheva Elena; Attar Erkut; Gurates Bilgin; Milad Magdy P; Confino Edmond; Su Emily; Reierstad Scott; Xue Qing

来源：Molecular and Cellular Endocrinology, 2009, 300(1-2): 104-108.

DOI：10.1016/j.mce.2008.12.012

• Endometriosis
• Steroidogenic factor-1
• Aromatase
• Estradiol
• Prostaglandin E2
• Estrogen biosynthesis
• StAR

Endometriosis is a common and chronic disease characterized by persistent pelvic pain and infertil, ity. Estradiol is essential for growth and inflammation in endometriotic tissue. The complete cascade of steroidogenic proteins/enzymes including aromatase is present in endometriosis leading to de novo estradiol synthesis. PGE(2) induces the expression of the genes that encode these enzymes. Upon PGE(2) treatment, coordinate recruitment of the nuclear receptor SF-1 to the promoters of these steroidogenic genes is the key event for estradiol synthesis. SF-1 is the key factor determining that an endometriotic cell will respond to PGE(2) by increased estradiol formation. The presence of SF-1 in endometriosis and its absence in endometrium is determined primarily by the methylation of its promoter. The key steroidogenic enzyme in endometriosis is aromatase encoded by a single gene because its inhibition blocks all estradiol biosynthesis. Aromatase inhibitors diminish endometriotic implants and associated pain refractory to existing treatments in affected women.

• 出版日期2009-3-5
• 单位西北大学