A Controversial Role for IL-12 in Immune Response and Bone Resorption at Apical Periodontal Sites

作者：Queiroz Junior Celso Martins; Barbosa Silva Marcelo Jose; Correa Joice Dias; Moreira Madeira Mila Fernandes; Garlet Thiago Pompermaier; Garlet Gustavo Pompermaier; Cunha Fernando Queiroz; Teixeira Mauro Martins; da Silva Tarcilia Aparecida^*

来源：Clinical and Developmental Immunology, 2010, 2010: 327417.

DOI：10.1155/2010/327417

Periapical lesions are inflammatory conditions of tooth periapical tissues, triggered by dental pulp infection and characterized by exudation of immune cells to the affected tissues and production of inflammatory mediators such as cytokines. The inflammatory periapical reaction is mainly driven by Th1, Th2, and Th17 responses, and such polarization may modulate progression of the disease and expression of bone proresorptive cytokines. IL-12 is a potent inducer of IFN-gamma production, which stimulates Th1 effector cells. Many evidences have shown a positive correlation between the bone resorptive cytokine IL-1 beta and the production of IL-12 and IFN-gamma. Furthermore, IL-12 may have a potential role in the release of bone resorptive mediators and blockade of Th2 cytokines, affecting the progression of periapical bone loss. Nevertheless, IL-12 and IFN-gamma have also been described as suppressors of osteoclast differentiation and activation, favoring bone maintenance. This paper focuses on the controversial roles of IL-12 in periapical lesions.

• 出版日期2010