Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease

作者：Lewis Patrick A^*; Alessi Dario R

来源：Biochemical Society Transactions, 2012, 40: 1039-1041.

DOI：10.1042/BST20120178

• cancer
• inflammatory bowel disease
• leprosy
• leucine-rich repeat kinase 2 (LRRK2)
• Parkinson%26apos
• s disease

LRRK2 (leucine-rich repeat kinase 2) is a gene of unknown function that has been linked to a number a human diseases, including PD (Parkinson%26apos;s disease), IBD (inflammatory bowel disease), leprosy and cancer. The papers from the LRRK2: Function and Dysfunction meeting in this issue of Biochemical Society Transactions explore our growing knowledge of LRRK2%26apos;s normal function, the role that it plays in disease and emerging strategies to exploit LRRK2 as a therapeutic target.

• 出版日期2012-10