The Cyclic Organosulfur Compound Zwiebelane A from Onion (Allium cepa) Functions as an Enhancer of Polymyxin B in Fungal Vacuole Disruption

作者：Borjihan Baiyinlang; Ogita Akira; Fujita Ken ichi; Doe Matsumi; Tanaka Toshio^*

来源：Planta Medica, 2010, 76(16): 1864-1866.

DOI：10.1055/s-0030-1249935

• Allium cepa
• Alliaceae
• zwiebelane A
• polymyxin B
• Saccharomyces cerevisiae

Zwiebelane A (cis-2,3-dimethyl-5,6-dithiabicyclo[2.1.1]hexane 5-oxide), a natural product of onion bulbs (Allium cepa L.), is found to enhance the potential fungicidal activity of polymyxin B (PMB). As is the case with allicin, an allyl sulfur compound from garlic, zwiebelane A amplifies the disruptive effect of PMB on the vacuole of Saccharomyces cerevisiae, which has been found to represent a target for antifungal agents.

• 出版日期2010-11