Activin A as a marker of intrauterine infection in women with preterm prelabour rupture of membranes

作者：Hodges R^*; Salvador L; D'Antona D; Georgiou H M; Wallace E M

来源：Journal of Perinatology, 2010, 30(1): 22-26.

DOI：10.1038/jp.2009.109

• activin
• intrauterine infection
• chorioamnionitis

Objective: To assess maternal serum activin A, an early phase response protein in systemic infection, as an early marker of intrauterine infection in women with preterm prelabour rupture of membranes (PPROM).
Study Design: A prospective cohort study of women with singleton pregnancies complicated by PPROM at 24 to 34 weeks' gestation. Serum was collected for activin A and cytokine measurements. Activin A was measured using commercial enzyme-linked immunosorbent assay. Cytokines were measured using commercial multiplex assay. Pregnancy outcomes including infection were determined by case-record review.
Result: Eighteen women with PPROM were studied, with seven developing intrauterine infection. Serum activin A in women with and without infection did not differ. Peripheral white cell count, interleukin (IL)-6 and IL-10 were higher (P = 0.03, 0.05 and 0.009, respectively) and IL-7 lower (P = 0.04) 72 h before delivery in women with infection.
Conclusion: Activin A is not a clinically useful marker of intrauterine infection in women with PPROM. Journal of Perinatology (2010) 30, 22-26; doi: 10.1038/jp.2009.109; published online 30 July 2009

• 出版日期2010-1
• 单位河北医科大学