DUAL REARRANGEMENT OF IMMUNOGLOBULIN AND T-CELL RECEPTOR GENE IN A CASE OF T-CELL HAIRY-CELL LEUKEMIA

作者：PALUMBO AP^*; CORRADINI P; BATTAGLIO S; OMEDE P; CODA R; BOCCADORO M; PILERI A

来源：European Journal of Haematology, 1991, 46(2): 71-76.

• HAIRY-CELL LEUKEMIA
• T-CELL MARKERS
• T-CELL RECEPTOR GENE
• IMMUNOGLOBULIN HEAVY-CHAIN GENES

We report a case of T-cell hairy-cell leukemia with a dual rearrangement of Ig- and T-cell receptor genes. The cytochemical, transmission electron microscopy, and surface antigens data (CD3+, CD8+, CD11+, HLA-DR+, CD19-, CD20-) were consistent with a T-cell hairy-cell leukemia. Molecular analysis according to Southern revealed a dual rearrangement of immunoglobulin heavy-chain (JH) and T-cell receptor beta (TcR-beta) chain genes. Our findings suggest that the coexistence of JH and TcR gene rearrangements, frequently detected in acute leukemia, may also be observed in hematologic malignancies derived from more differentiated cells.

• 出版日期1991-2