Assessment of Cerebral Hemodynamics to Acetazolamide Using Brain Perfusion SPECT in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

作者：Park Soon Ah; Yang Chung Yong^*; Choi See Sung; Kim Woo Hyoung

来源：Clinical Nuclear Medicine, 2011, 36(2): 158-159.

DOI：10.1097/RLU.0b013e3182073c0f

• CADASIL
• acetazolamide
• brain
• SPECT

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary microangiopathy caused by mutations in the Notch3 gene located on chromosome 19, leading to 4 cardinal features with aura, cerebrovascular ischemic events, mood disturbances, and dementia. Acetazolamide (ACZ) has been promoted as a drug to determine cerebral hemodynamics, including cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in patients with cerebrovascular disease. In CADASIL patients with small-vessel disease, ACZ may be possible to increase CBF. We present that reduced CBF was dramatically improved after administration of ACZ on Tc-99m ECD brain perfusion SPECT in a CADASIL patient.

• 出版日期2011-2