Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

作者：Nicol James R; Dixon Dorian; Coulter Jonathan A^*

来源：Nanomedicine, 2015, 10(8): 1315-1326.

DOI：10.2217/nnm.14.219

• bottom-up synthesis
• gold
• nanoparticle
• nanoparticle functionalization
• nanoparticle stability
• organelle targeting

With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.

• 出版日期2015