An analysis of the molecular evolution of Hepatitis B viral genotypes A/B/D using a Bayesian evolutionary method

作者：Xu, Guangyu; Wei, Chengguo; Guo, Yuqi; Zhang, Chao; Zhang, Nan^*; Wang, Guoqing

来源：Virology Journal, 2013, 10: 256.

DOI：10.1186/1743-422X-10-256

• HBV
• Genotypes
• Bayesian analyses
• TMRCA

Background: Hepatitis B virus (HBV) infection is a major global health problem. The infectious virion contains an inner "core particle", which is made of 180 or 240 copies of core protein, alternatively known as hepatitis B core antigen, or HBcAg which encloses the viral genome. @@@ Method: In this study, we characterized HBV genotypes and used Bayesian analyses to estimate date of emergence of the most recent common ancestor (TMRCA) of three HBV genotypes, A, B, and D. @@@ Results: We estimated that the rate of evolution of HBV core protein gene to be 1.127 (0.925-1.329, 95% HPD) substitutions per site per year. The TMRCA of HBV for genotypes A, B, D were 118 (54-194, 95% HPD) year, 184 (78-323, 95% HPD) year and 133 (65-230, 95% HPD) year, respectively. Demographic histories of the HBcAg gene showed that the relative genetic diversity had a sharp increase within the first 10 years of its emergence. @@@ Conclusion: Using a bayesian evolutionary method to predict the outbreak trends of HBV through evolutionary trees of HBV, and provide theoretical foundations for clinical prevention and treatment of HBV.

• 出版日期2013-8-10
• 单位北华大学; 吉林大学