Application of spectroscopy ((HMRS)-H-1) to assess liver metabolite concentrations in rats with intrauterine growth restriction

作者：Wang, Tao; Chen, Pingyang^*; Bian, Dujun; Chen, Juncao

来源：Journal of Maternal-Fetal and Neonatal Medicine, 2017, 30(8): 1001-1004.

DOI：10.1080/14767058.2016.1174989

• Intrauterine growth retardation
• liver metabolism
• proton magnetic resonance spectroscopy

Objective: Proton magnetic resonance spectroscopy (H-1-MRS) measurement of liver metabolism in intrauterine growth restriction rats has seldom been reported. This study investigated the application of H-1-MRS in assessing liver metabolism in newborn pups that experienced intrauterine growth restriction.Methods: Intra-uterine growth restriction was established by feeding rats low-protein diets during pregnancy. Newborn pups received conventional magnetic resonance imaging and H-1-MRS using a 3.0T whole body MR scanner at 3, 8 and 12 weeks post birth.Results: The success rate of H-1-MRS was 83.33%. Significantly lower body weight, BMI and body length at 3 weeks as well as significantly lower body weight, BMI and waist circumference at 8 and 12 weeks were observed in newborn pups of IUGR rats compared with pups of control rats. Significant differences in ACho/H2O, ACr/H2O, AGlx/H2O and ALipid/H2O at 3 and 8 weeks as well as significant differences in ACr/H2O, ALipid/H2O and AGlx/H2O at 12 weeks were observed between pups of control rats and pups of IUGR rats.Conclusion: H-1-MRS allows noninvasive assessment of liver metabolism in the rat and demonstrated the poor liver development of rats that experienced IUGR.

• 出版日期2017-4
• 单位中南大学